ASF1B

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesASF1B, CIA-II, anti-silencing function 1B histone chaperone
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ASF1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesASF1B, CIA-II, anti-silencing function 1B histone chaperone
External IDsOMIM: 609190; MGI: 1914179; HomoloGene: 56797; GeneCards: ASF1B; OMA:ASF1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018154

NM_024184

RefSeq (protein)

NP_060624

NP_077146

Location (UCSC)Chr 19: 14.12 – 14.14 MbChr 8: 84.68 – 84.7 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.[7]

Interactions

ASF1B has been shown to interact with TLK2,[6][8] CHAF1B,[5][8] TLK1[6][8] and CHAF1A.[5][8]

References

Further reading

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