ASH2L

Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesASH2L, ASH2, ASH2L1, ASH2L2, Bre2, ASH2 like histone lysine methyltransferase complex subunit, ASH2 like, histone lysine methyltransferase complex subunit

External IDsOMIM: 604782; MGI: 1344416; HomoloGene: 3436; GeneCards: ASH2L; OMA:ASH2L - orthologs

Chr.Chromosome 8 (human)^[1]

Quick facts Available structures, PDB ...

ASH2L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RSN, 3S32, 3TOJ, 4RIQ, 4X8N, 4X8P, 5F6L, 5F6K
Identifiers
Aliases	ASH2L, ASH2, ASH2L1, ASH2L2, Bre2, ASH2 like histone lysine methyltransferase complex subunit, ASH2 like, histone lysine methyltransferase complex subunit
External IDs	OMIM: 604782; MGI: 1344416; HomoloGene: 3436; GeneCards: ASH2L; OMA:ASH2L - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 38,105,493 bp[1] End 38,144,076 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 26,306,024 bp[2] End 26,337,722 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery germinal epithelium gonad trabecular bone gingival epithelium ventricular zone tibialis anterior muscle embryo mucosa of paranasal sinus right testis Top expressed in seminiferous tubule spermatocyte maxillary prominence blastocyst mandibular prominence yolk sac ventricular zone medial ganglionic eminence spermatid abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function euchromatin binding beta-catenin binding histone methyltransferase activity (H3-K4 specific) metal ion binding protein binding histone-lysine N-methyltransferase activity DNA binding Cellular component nucleoplasm MLL1 complex MLL3/4 complex nucleus histone methyltransferase complex Set1C/COMPASS complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus response to estrogen positive regulation of cell population proliferation positive regulation of transcription by RNA polymerase II beta-catenin-TCF complex assembly regulation of megakaryocyte differentiation histone H3-K4 methylation chromatin organization hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9070 23808 Ensembl ENSG00000129691 ENSMUSG00000031575 UniProt Q9UBL3 Q91X20 RefSeq (mRNA) NM_001105214 NM_001261832 NM_001282272 NM_004674 NM_001080793 NM_001286207 NM_011791 NM_001359012 RefSeq (protein) NP_001098684 NP_001248761 NP_001269201 NP_004665 NP_001074262 NP_001273136 NP_035921 NP_001345941 Location (UCSC) Chr 8: 38.11 – 38.14 Mb Chr 8: 26.31 – 26.34 Mb PubMed search [3] [4]
Wikidata
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