ATF6

ATF6
Identifiers
Aliases	ATF6, ATF6A, ACHM7, activating transcription factor 6
External IDs	OMIM: 605537; MGI: 1926157; HomoloGene: 32015; GeneCards: ATF6; OMA:ATF6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,977,574 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,695,340 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; skin of hip; ; skin of thigh; ; retinal pigment epithelium; ; tail of epididymis; ; synovial joint; ; caput epididymis; ; seminal vesicula; ; saphenous vein; ; endothelial cell;
	Top expressed in
	myocardium of ventricle; ; lacrimal gland; ; submandibular gland; ; cardiac muscles; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; seminal vesicula; ; secondary oocyte; ; stroma of bone marrow; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; transcription cis-regulatory region binding; protein binding; identical protein binding; protein heterodimerization activity; ubiquitin protein ligase binding; cAMP response element binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	integral component of membrane; Golgi apparatus; nuclear envelope; membrane; endoplasmic reticulum membrane; Golgi membrane; nucleoplasm; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; nucleus; cytosol;
Biological process	eye development; regulation of transcription, DNA-templated; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; regulation of transcription by RNA polymerase II; transcription, DNA-templated; endoplasmic reticulum unfolded protein response; ATF6-mediated unfolded protein response; response to unfolded protein; protein folding; signal transduction; visual perception; positive regulation of apoptotic process; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of ATF6-mediated unfolded protein response;
	Sources:Amigo / QuickGO
Orthologs
	22926
	226641
	ENSG00000118217
	ENSMUSG00000026663
	P18850
	F6VAN0
	NM_007348
	NM_001081304
	NP_031374
	NP_001074773
	Wikidata
View/Edit Human	View/Edit Mouse

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene^[5]^[6]^[7] and is involved in the unfolded protein response.