ATF7IP

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesATF7IP, AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
Quick facts Available structures, PDB ...
ATF7IP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATF7IP, AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
External IDsOMIM: 613644; MGI: 1858965; HomoloGene: 10051; GeneCards: ATF7IP; OMA:ATF7IP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286514
NM_001286515
NM_018179
NM_181352

NM_019426

RefSeq (protein)

NP_001273443
NP_001273444
NP_060649
NP_851997
NP_060649.3

NP_062299
NP_001375123
NP_001375124
NP_001375125
NP_001375126

Location (UCSC)Chr 12: 14.37 – 14.5 MbChr 6: 136.51 – 136.61 Mb
PubMed search[3][4]
Wikidata
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Interactions

ATF7IP has been shown to interact with MBD1.[8] In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.[9][10]

References

Further reading

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