Cysteine protease ATG4A

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase, HsAPG4A

External IDsOMIM: 300663; MGI: 2147903; HomoloGene: 70873; GeneCards: ATG4A; OMA:ATG4A - orthologs

Chr.X chromosome (human)^[1]

Quick facts ATG4A, Available structures ...

ATG4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P82
Identifiers
Aliases	ATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase, HsAPG4A
External IDs	OMIM: 300663; MGI: 2147903; HomoloGene: 70873; GeneCards: ATG4A; OMA:ATG4A - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.3 Start 108,091,668 bp[1] End 108,154,671 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F1 Start 140,956,907 bp[2] End 141,164,270 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas gastrocnemius muscle muscle of thigh rectum islet of Langerhans tibialis anterior muscle anterior pituitary left ventricle deltoid muscle right lung Top expressed in bone marrow quadriceps femoris muscle muscle of thigh proximal tubule muscle tissue right kidney skeletal muscle tissue ileum granulocyte lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity protein binding hydrolase activity cysteine-type endopeptidase activity Cellular component cytoplasm cytosol Biological process autophagy protein transport autophagy of nucleus C-terminal protein lipidation protein delipidation autophagy of mitochondrion autophagosome assembly proteolysis protein targeting to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115201 666468 Ensembl ENSG00000101844 ENSMUSG00000079418 UniProt Q8WYN0 Q8C9S8 RefSeq (mRNA) NM_052936 NM_178270 NM_178271 NM_001321287 NM_001321288 NM_001321289 NM_001321290 NM_174875 RefSeq (protein) NP_001308216 NP_001308217 NP_001308218 NP_001308219 NP_443168 NP_840054 NP_840055 NP_777364 NP_001366610 NP_001366611 NP_001366612 NP_001366613 Location (UCSC) Chr X: 108.09 – 108.15 Mb Chr X: 140.96 – 141.16 Mb PubMed search [3] [4]
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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.^[6]