ATG9A

Autophagy-related protein 9A is a protein that in humans is encoded by the ATG9A gene.^[5]

AliasesATG9A, APG9L1, MGD3208, mATG9, autophagy related 9A

External IDsOMIM: 612204; MGI: 2138446; HomoloGene: 34495; GeneCards: ATG9A; OMA:ATG9A - orthologs

Chr.Chromosome 2 (human)^[1]

End219,229,717 bp^[1]

Quick facts Identifiers, Aliases ...

ATG9A
Identifiers
Aliases	ATG9A, APG9L1, MGD3208, mATG9, autophagy related 9A
External IDs	OMIM: 612204; MGI: 2138446; HomoloGene: 34495; GeneCards: ATG9A; OMA:ATG9A - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 219,219,380 bp[1] End 219,229,717 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 75,157,504 bp[2] End 75,168,840 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue apex of heart muscle of thigh left testis right testis blood stromal cell of endometrium left ventricle prefrontal cortex Top expressed in muscle of thigh testicle skeletal muscle tissue quadriceps femoris muscle spermatid granulocyte striatum of neuraxis superior frontal gyrus primary visual cortex cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane recycling endosome endosome late endosome Golgi apparatus endoplasmic reticulum membrane membrane late endosome membrane phagophore assembly site trans-Golgi network autophagosome membrane endoplasmic reticulum cytoplasmic vesicle autophagosome intracellular membrane-bounded organelle cytoplasmic vesicle membrane Biological process protein localization to phagophore assembly site autophagosome assembly autophagy autophagy of mitochondrion late nucleophagy protein transport response to nutrient levels transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79065 245860 Ensembl ENSG00000198925 ENSMUSG00000033124 UniProt Q7Z3C6 Q68FE2 RefSeq (mRNA) NM_001077198 NM_024085 NM_001003917 NM_001288612 NM_001288613 RefSeq (protein) NP_001070666 NP_076990 NP_001070666.1 NP_076990.4 NP_001003917 NP_001275541 NP_001275542 NP_001395154 NP_001395156 NP_001395158 NP_001395159 NP_001395160 Location (UCSC) Chr 2: 219.22 – 219.23 Mb Chr 1: 75.16 – 75.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Functional studies indicate that ATG9A plays a role in autophagy.^[6][7] and other non-autophagy membrane remodeling processes such as plasma membrane repair.^[8] Enzymatically, it is a lipid scramblase.^[6][7] ATG9A interacts with IQGAP1 and the ESCRT machinery in membrane remodeling.^[8]