ATP13A2

ATP13A2
Identifiers
Aliases	ATP13A2, CLN12, HSA9947, KRPPD, PARK9, ATPase 13A2, SPG78, ATPase cation transporting 13A2
External IDs	OMIM: 610513; MGI: 1922022; HomoloGene: 56940; GeneCards: ATP13A2; OMA:ATP13A2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	17,011,928 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,734,641 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; prefrontal cortex; ; anterior cingulate cortex; ; pons; ; Brodmann area 9; ; anterior pituitary; ; amygdala; ; hypothalamus; ; nucleus accumbens;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; stroma of bone marrow; ; dorsal tegmental nucleus; ; perirhinal cortex; ; neural layer of retina; ; motor neuron; ; entorhinal cortex; ; superior colliculus; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; metal ion binding; ATPase activity; protein binding; hydrolase activity; ATP binding; cupric ion binding; phosphatidic acid binding; zinc ion binding; phosphatidylinositol-3,5-bisphosphate binding; manganese ion binding; P-type calcium transporter activity; ATPase-coupled cation transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; vesicle membrane; integral component of plasma membrane; transport vesicle; lysosomal lumen; lysosome; vesicle; multivesicular body; neuron projection; integral component of lysosomal membrane; multivesicular body membrane; autophagosome; late endosome; soma; lysosomal membrane;
Biological process	cellular cation homeostasis; cation transport; ion transmembrane transport; regulation of autophagy of mitochondrion; regulation of autophagosome size; regulation of endopeptidase activity; regulation of mitochondrion organization; cellular response to oxidative stress; cellular calcium ion homeostasis; cellular response to manganese ion; cellular iron ion homeostasis; protein autophosphorylation; cellular zinc ion homeostasis; autophagosome organization; regulation of glucosylceramidase activity; regulation of chaperone-mediated autophagy; negative regulation of neuron death; zinc ion homeostasis; regulation of macroautophagy; regulation of intracellular protein transport; positive regulation of protein secretion; positive regulation of exosomal secretion; peptidyl-aspartic acid autophosphorylation; negative regulation of lysosomal protein catabolic process; cellular response to zinc ion; calcium ion transmembrane transport; regulation of lysosomal protein catabolic process; extracellular exosome biogenesis; polyamine transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	23400
	74772
	ENSG00000159363
	ENSMUSG00000036622
	Q9NQ11; Q8N4D4
	Q9CTG6
	NM_001141973; NM_001141974; NM_022089
NM_001164366; NM_029097; NM_001379619; NM_001379620; NM_001379621;
	NM_001379622
	NP_001135445; NP_001135446; NP_071372; NP_001135445.1; NP_001135446.1
NP_001157838; NP_083373; NP_001366548; NP_001366549; NP_001366550;
	NP_001366551
	Wikidata
View/Edit Human	View/Edit Mouse

Probable cation-transporting ATPase 13A2 is an enzyme that in humans is encoded by the ATP13A2 gene that is involved in the transport of divalent transition metal cations.^[5]^[6]^[7] It appears to protect cells from manganese^[8] and zinc toxicity,^[9] possibly by causing cellular efflux and/or lysosomal sequestration; and from iron toxicity, possibly by preserving lysosome integrity against iron-induced lipid peroxidation.^[10] However, it potentiates the toxic effects of cadmium and nickel on developing neurites,^[11] and of the widely used herbicide paraquat^[12] possibly by increasing polyamine uptake.^[13]