ATP1B3

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene.^[5][6][7] ATP1B3 has also been designated as CD298 (cluster of differentiation 298).

AliasesATP1B3, ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3

External IDsOMIM: 601867; MGI: 107788; HomoloGene: 37510; GeneCards: ATP1B3; OMA:ATP1B3 - orthologs

Chr.Chromosome 3 (human)^[1]

End141,926,549 bp^[1]

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ATP1B3
Identifiers
Aliases	ATP1B3, ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3
External IDs	OMIM: 601867; MGI: 107788; HomoloGene: 37510; GeneCards: ATP1B3; OMA:ATP1B3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 141,876,124 bp[1] End 141,926,549 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.3|9 50.31 cM Start 96,214,708 bp[2] End 96,246,495 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm skin of thigh skin of hip gingival epithelium mucosa of colon mucosa of pharynx stromal cell of endometrium vulva mucosa of sigmoid colon mucosa of transverse colon Top expressed in sciatic nerve epithelium of lens seminiferous tubule choroid plexus of fourth ventricle corneal stroma gastrula molar utricle skin of external ear superior surface of tongue More reference expression data BioGPS n/a
Gene ontology Molecular function ATPase binding P-type sodium:potassium-exchanging transporter activity ATPase activator activity Cellular component cytoplasm integral component of membrane membrane melanosome plasma membrane sodium:potassium-exchanging ATPase complex caveola extracellular exosome Biological process regulation of cardiac conduction positive regulation of ATP-dependent activity positive regulation of sodium ion export across plasma membrane sodium ion transport cellular sodium ion homeostasis sodium ion export across plasma membrane metal ion transport positive regulation of potassium ion import across plasma membrane protein stabilization ion transport cellular potassium ion homeostasis potassium ion transport membrane repolarization ion transmembrane transport protein localization to plasma membrane leukocyte migration positive regulation of potassium ion transmembrane transporter activity establishment or maintenance of transmembrane electrochemical gradient transport potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 483 11933 Ensembl ENSG00000069849 ENSMUSG00000032412 UniProt P54709 P97370 RefSeq (mRNA) NM_001679 NM_007502 NM_001357212 NM_001357213 RefSeq (protein) NP_001670 NP_031528 NP_001344141 NP_001344142 Location (UCSC) Chr 3: 141.88 – 141.93 Mb Chr 9: 96.21 – 96.25 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.^[7]