ATP2A2

ATP2A2 also known as sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is an ATPase associated with Darier's disease^[5] and Acrokeratosis verruciformis.

AliasesATP2A2, ATP2B, DAR, DD, SERCA2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

External IDsOMIM: 108740; MGI: 88110; HomoloGene: 80167; GeneCards: ATP2A2; OMA:ATP2A2 - orthologs

Chr.Chromosome 12 (human)^[1]

End110,351,093 bp^[1]

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ATP2A2
Identifiers
Aliases	ATP2A2, ATP2B, DAR, DD, SERCA2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
External IDs	OMIM: 108740; MGI: 88110; HomoloGene: 80167; GeneCards: ATP2A2; OMA:ATP2A2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 110,280,756 bp[1] End 110,351,093 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 62.38 cM|5 F Start 122,591,576 bp[2] End 122,640,288 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii right ventricle body of tongue triceps brachii muscle glutes Skeletal muscle tissue of rectus abdominis thoracic diaphragm right auricle of heart vena cava lateral nuclear group of thalamus Top expressed in myocardium of ventricle atrium cardiac muscles cardiac muscle tissue of left ventricle interventricular septum medial dorsal nucleus atrioventricular valve soleus muscle right ventricle lateral geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding calcium ion binding S100 protein binding P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential metal ion binding protein binding enzyme binding hydrolase activity ATP binding P-type calcium transporter activity protein C-terminus binding lutropin-choriogonadotropic hormone receptor binding P-type proton-exporting transporter activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane vesicle membrane intercalated disc extrinsic component of cytoplasmic side of plasma membrane integral component of plasma membrane sarcoplasmic reticulum ribbon synapse longitudinal sarcoplasmic reticulum platelet dense tubular network membrane endoplasmic reticulum sarcoplasmic reticulum membrane perinuclear region of cytoplasm calcium ion-transporting ATPase complex nucleoplasm protein-containing complex apical ectoplasmic specialization plasma membrane bounded cell projection Biological process regulation of cardiac conduction regulation of cardiac muscle contraction by calcium ion signaling regulation of calcium ion-dependent exocytosis of neurotransmitter negative regulation of heart contraction transition between fast and slow fiber regulation of the force of heart contraction regulation of cardiac muscle cell action potential involved in regulation of contraction cellular calcium ion homeostasis positive regulation of endoplasmic reticulum calcium ion concentration ion transport endoplasmic reticulum calcium ion homeostasis ER-nucleus signaling pathway organelle organization positive regulation of heart rate ion transmembrane transport cell adhesion calcium ion transmembrane transport sarcoplasmic reticulum calcium ion transport calcium ion transport from cytosol to endoplasmic reticulum epidermis development cellular response to oxidative stress calcium ion import into sarcoplasmic reticulum regulation of cardiac muscle cell membrane potential relaxation of cardiac muscle calcium ion transport T-tubule organization cardiac muscle hypertrophy in response to stress response to endoplasmic reticulum stress response to lipopolysaccharide skeletal muscle contraction cellular response to heat proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 488 11938 Ensembl ENSG00000174437 ENSMUSG00000029467 UniProt P16615 O55143 RefSeq (mRNA) NM_001135765 NM_001681 NM_170665 NM_001110140 NM_009722 RefSeq (protein) NP_001672 NP_733765 NP_001103610 NP_033852 Location (UCSC) Chr 12: 110.28 – 110.35 Mb Chr 5: 122.59 – 122.64 Mb PubMed search [3] [4]
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This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells.^[6] This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.