AZIN2

AZIN2
Identifiers
Aliases	AZIN2, ADC, AZI2, ODC-p, ODC1L, ODCp, AZIB1, antizyme inhibitor 2
External IDs	OMIM: 608353; MGI: 2442093; HomoloGene: 62172; GeneCards: AZIN2; OMA:AZIN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	33,123,492 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	128,856,235 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; C1 segment; ; prefrontal cortex; ; corpus callosum; ; Brodmann area 9; ; right frontal lobe; ; substantia nigra; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	seminiferous tubule; ; spermatid; ; lumbar spinal ganglion; ; dentate gyrus of hippocampal formation granule cell; ; lens; ; spermatocyte; ; primary visual cortex; ; superior frontal gyrus; ; Rostral migratory stream; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	putrescine transmembrane transporter activity; catalytic activity; protein binding; ornithine decarboxylase activator activity; arginine decarboxylase activity; ornithine decarboxylase activity;
Cellular component	transport vesicle; cytoplasm; mitochondrion; trans-Golgi network; cell projection; Golgi apparatus; nucleus; axon; granular vesicle; membrane; dendrite; perinuclear region of cytoplasm; cis-Golgi network; cytoplasmic vesicle; perikaryon; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum-Golgi intermediate compartment; cytosol;
Biological process	positive regulation of polyamine transmembrane transport; spermatogenesis; putrescine transport; ornithine metabolic process; putrescine biosynthetic process from ornithine; trans-Golgi network membrane organization; agmatine biosynthetic process; positive regulation of catalytic activity; polyamine biosynthetic process; negative regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	113451
	242669
	ENSG00000142920
	ENSMUSG00000028789
	Q96A70
	Q8BVM4
NM_001293562; NM_001301823; NM_001301824; NM_001301825; NM_001301826;
	NM_052998; NM_001350398; NM_001350399; NM_001350400; NM_001350401; NM_001350402; NM_001376722; NM_001376724; NM_001376725; NM_001376727; NM_001376729; NM_001376730; NM_001376732
	NM_001301841; NM_172875
NP_001280491; NP_001288752; NP_001288753; NP_001288754; NP_001288755;
	NP_443724; NP_001337327; NP_001337328; NP_001337329; NP_001337330; NP_001337331; NP_001363651; NP_001363653; NP_001363654; NP_001363656; NP_001363658; NP_001363659; NP_001363661
	NP_001288770; NP_766463
	Wikidata
View/Edit Human	View/Edit Mouse

Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene.^[5]^[6]^[7] In contrast to initial suggestions,^[5] Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells ^[8]^[9]