Abafungin

Chemical compound From Wikipedia, the free encyclopedia

Abafungin (INN) is a broad-spectrum arylguanidines-class antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.[1]

Trade namesAbasol
Routes of
administrationTopical (cream)
ATC code
  • none
CAS Number
Quick facts Clinical data, Trade names ...
Abafungin
Structural formula of abafungin
Space-filling model of the abafungin molecule
Clinical data
Trade namesAbasol
Routes of
administration		Topical (cream)
ATC code
  • none
Identifiers
  • N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.125.129 Edit this at Wikidata
Chemical and physical data
FormulaC21H22N4OS
Molar mass378.49 g·mol−1
3D model (JSmol)
  • CC1=CC(=C(C=C1)OC2=CC=CC=C2C3=CSC(=N3)NC4=NCCCN4)C
  • InChI=1S/C21H22N4OS/c1-14-8-9-18(15(2)12-14)26-19-7-4-3-6-16(19)17-13-27-21(24-17)25-20-22-10-5-11-23-20/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H2,22,23,24,25) checkY
  • Key:TYBHXIFFPVFXQW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)
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Abasol is a topical cream formulation of abafungin by York Pharma.[2]

History

Abafungin was first synthesized at Bayer AG, Leverkusen, Germany. A study of H2-antagonists related to famotidine, resulted in the discovery of its antifungal properties.[3]

Its development seems to have been discontinued in 2009.[4]

Mechanism of action

Unlike imidazole- and triazole-class antifungals, abafungin directly impairs the fungal cell membrane.[3]

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.[5]

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.[6]

References

External links

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