Acedapsone

Acedapsone (INN) is an antimicrobial drug, which also has antimalarial activity.

Trade namesRodilone
Hansolar

ATC code

• none

CAS Number

• 77-46-3 ^N

PubChem CID

• 6477

Quick facts Clinical data, Trade names ...

Acedapsone

Clinical data
Trade names	Rodilone Hansolar
ATC code	none
Identifiers
IUPAC name N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide
CAS Number	77-46-3 N
PubChem CID	6477
ChemSpider	6232 Y
UNII	0GZ72U84TN
KEGG	D02751 Y
ChEMBL	ChEMBL154166 Y
CompTox Dashboard (EPA)	DTXSID1021295
ECHA InfoCard	100.000.936
Chemical and physical data
Formula	C16H16N2O4S
Molar mass	332.37 g·mol−1
3D model (JSmol)	Interactive image
Melting point	290 °C (554 °F)
SMILES CC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C
InChI InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20) Y Key:AMTPYFGPPVFBBI-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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Acedapsone is the INN for diacetyldapsone. It was synthesized and developed in 1937 by Ernest Fourneau and his team in the pharmaceutical chemistry laboratory of Pasteur Institute,^[1] and it was marketed as Rodilone by the Rhône-Poulenc company.^[2]

It is a long-acting prodrug of dapsone. It is used for treating leprosy.^[3]

It crystallises as pale yellow needles from diethyl ether, and as leaflets from dilute ethanol. It is slightly soluble in water.^{[citation needed]}