Α-Galactosidase
Enzyme
From Wikipedia, the free encyclopedia
α-Galactosidase ( EC 3.2.1.22, α-GAL, α-GAL A; systematic name α-D-galactoside galactohydrolase) is a glycoside hydrolase enzyme that catalyses the following reaction:[1]
- Hydrolysis of terminal, non-reducing α-D-galactose residues in α-D-galactosides, including galactooligosaccharides (GOS), galactomannans and galactolipids
| α-Galactosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
α-Galactosidase tetramer in Mortierella vinacea | |||||||||
| Identifiers | |||||||||
| EC no. | 3.2.1.22 | ||||||||
| CAS no. | 9025-35-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
It catalyzes many catabolic processes, including cleavage of glycoproteins, glycolipids, and polysaccharides.
Function
This enzyme is a homodimeric glycoprotein that hydrolyses the terminal α-galactosyl moieties from glycolipids and glycoproteins. It predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose.[citation needed]
Reaction mechanism
Applications
See also
- β-galactosidase
- Migalastat, a drug targeting α-galactosidase
- Classification of α-galactosidases (according to CAZy)
