Akkermansia
Genus of bacteria
From Wikipedia, the free encyclopedia
Akkermansia is a genus in the phylum Verrucomicrobiota (Bacteria).[2] The genus was first proposed by Derrien et al. (2004), with the type species Akkermansia muciniphila (gen. nov., sp. nov).[1]
| Akkermansia | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Pseudomonadati |
| Phylum: | Verrucomicrobiota |
| Class: | Verrucomicrobiia |
| Order: | Verrucomicrobiales |
| Family: | Akkermansiaceae |
| Genus: | Akkermansia Derrien et al. 2004[1] |
| Type species | |
| Akkermansia muciniphila Derrien et al. 2004 | |
| Species[2] | |
| |
Until 2016 the genus contained a single known species, namely A. muciniphila.[2] In 2016, Akkermansia glycaniphila was isolated in the feces of a reticulated python.[3]
Etymology
The name Akkermansia (Ak.ker.man'si.a.) derives from: Neo-Latin feminine gender noun Akkermansia, named after Anton Dirk Louis Akkermans (1940–2006),[4] a Dutch microbiologist recognized for his contribution to microbial ecology.[2] Neo-Latin neuter gender noun mucinum, mucin; Neo-Latin adjective philus from Greek adjective philos (φίλος) meaning friend, loving; Neo-Latin feminine gender adjective muciniphila, mucin-loving).[1]
Description
Cells are oval-shaped, non-motile and stain Gram-negative. Strictly anaerobic organism. Chemo-organotrophic. Mucolytic in pure culture.[1]: 1474
Phylogeny
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[2] and National Center for Biotechnology Information (NCBI).[5]
| 16S rRNA based LTP_10_2024[6][7][8] | 120 marker proteins based GTDB 10-RS226[9][10][11] | ||||||||||||||||||||||||||||||||||||||||||||||||
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Human metabolism
Akkermansia muciniphila can reside in the human intestinal tract and is currently being studied for its effects on human metabolism and health.[12] It could be of interest for the treatment of obesity and type 2 diabetes. Akkermansia has been shown to reverse high-fat diet-induced metabolic disorders in mice by increasing intestinal levels of endocannabinoids (e.g. 2-arachidonoylglycerol and 2-oleoylglycerol) and mucosal thickness.[13][14][15] Another study showed that Akkermansia muciniphila alleviates depression-like behavior by regulating gut microbiota and metabolites in a chronic stress mouse model.[16]
