Allobarbital

Allobarbital, also known as allobarbitone and branded as Dial, Cibalgine (in combination with aminophenazone), or Dial-Ciba (in combination with ethyl carbamate), is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant^[2] although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of analgesic drugs, and use in the treatment of insomnia and anxiety.

Other names5,5-Diallylbarbituric acid, Diallylmalonylurea

Drug classBarbiturate

ATC code

• N05CA21 (WHO)

Legal status

• BR: Class B1 (Psychoactive drugs)^[1]
• CA: Schedule IV
• DE: Anlage III (Special prescription form required)
• US: Schedule III

Quick facts Clinical data, Other names ...

Allobarbital

Clinical data
Other names	5,5-Diallylbarbituric acid, Diallylmalonylurea
Drug class	Barbiturate
ATC code	N05CA21 (WHO)
Legal status
Legal status	BR: Class B1 (Psychoactive drugs)[1] CA: Schedule IV DE: Anlage III (Special prescription form required) US: Schedule III
Identifiers
IUPAC name 5,5-di(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
CAS Number	52-43-7 Y
PubChem CID	5842
ChemSpider	5635 Y
UNII	8NT43GG2HA
KEGG	D02817 Y
ChEMBL	ChEMBL267719 Y
CompTox Dashboard (EPA)	DTXSID9022572
ECHA InfoCard	100.000.129
Chemical and physical data
Formula	C10H12N2O3
Molar mass	208.217 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C1NC(=O)NC(=O)C1(C\C=C)C\C=C
InChI InChI=1S/C10H12N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-4H,1-2,5-6H2,(H2,11,12,13,14,15) Y Key:FDQGNLOWMMVRQL-UHFFFAOYSA-N Y
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Allobarbital was never particularly widely used compared to better known barbiturates such as phenobarbital and secobarbital, although it saw more use in some European countries such as Bulgaria and Slovakia.^[3] In Poland, it was used until the 2010's, but only as compound.^[4]