Α-Mannosidase
Class of enzymes
From Wikipedia, the free encyclopedia
α-Mannosidase (EC 3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.[3][4]
| α-Mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 α-Mannosidase 1, tetramer, Saccharomyces cerevisiae | |||||||||
| Identifiers | |||||||||
| EC no. | 3.2.1.24 | ||||||||
| CAS no. | 9025-42-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Isoenzymes
Humans express the following three α-mannosidase isoenzymes:
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Applications
It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.[5]
Pathology
A deficiency can lead to α-mannosidosis.[6]
