Altinicline

Altinicline
Clinical data
ATC code	None;
Identifiers
	IUPAC name (2S)-3-ethynyl-5-(1-methylpyrrolidin-2-yl)pyridine;
CAS Number	179120-92-4 ;
PubChem CID	3036156;
ChemSpider	2300234 ;
UNII	RJ9V9V09VM;
ChEMBL	ChEMBL111659 ;
CompTox Dashboard (EPA)	DTXSID40870143 ;
Chemical and physical data
Formula	C12H14N2
Molar mass	186.258 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c2ncc(C#C)cc2C1CCCN1C;
	InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1 ; Key:NUPUDYKEEJNZRG-LBPRGKRZSA-N ;
	(verify)

Altinicline (SIB-1508Y, SIB-1765F) is a drug which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype.^[1]^[2] It stimulates release of dopamine and acetylcholine in the brain in both rodent and primate models,^[3] and progressed as far as Phase II clinical trials for Parkinson's disease,^[4] where "no antiparkinsonian or cognitive-enhancing effects were demonstrated", although its current status is unclear.

ATC code

None

CAS Number

179120-92-4^Y

PubChem CID

3036156

ChemSpider

2300234^Y

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Altinicline

References

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