Amidephrine

Amidephrine (BANTooltip British Approved Name), or amidefrine, sold under the brand name Fentrinol among others, is a selective α₁-adrenergic receptor agonist which is described as an adrenergic or sympathomimetic, vasoconstrictor, and topical nasal decongestant used to treat allergic rhinitis.^{[1][2][3][4][5]} It is used as the mesylate salt, which has the generic names amidefrine mesilate (INNTooltip International Nonproprietary Name) and amidephrine mesylate (USANTooltip United States Adopted Name).^[2] The drug is a substituted phenethylamine derivative and is also known as 3-methylsulfonamidyl-β-hydroxy-N-methylphenethylamine.^[2][1][6] As of 2000, it remained marketed only in Austria.^[3]

Trade namesDricol, Fentrinol, Nalde

Other namesAmidefrine; MJ-1996; MJ-5190; 3-Methylsulfonamidyl-β-hydroxy-N-methylphenethylamine; 3-Methylsulfonamidyl-β-hydroxy-N-methyl-β-phenylethylamine

ATC code

• None

CAS Number

• 37571-84-9 ^Y
  1421-68-7 (mesylate)

Quick facts Clinical data, Trade names ...

Amidephrine

Clinical data
Trade names	Dricol, Fentrinol, Nalde
Other names	Amidefrine; MJ-1996; MJ-5190; 3-Methylsulfonamidyl-β-hydroxy-N-methylphenethylamine; 3-Methylsulfonamidyl-β-hydroxy-N-methyl-β-phenylethylamine
ATC code	None
Identifiers
IUPAC name (RS)-N-{3-[1-hydroxy-2-(methylamino)ethyl]phenyl}methanesulfonamide
CAS Number	37571-84-9 Y 1421-68-7 (mesylate)
PubChem CID	15010
IUPHAR/BPS	514
DrugBank	DB16623
ChemSpider	14288 Y
UNII	7E2P22546V
ChEMBL	ChEMBL146408 Y
CompTox Dashboard (EPA)	DTXSID40862664
Chemical and physical data
Formula	C10H16N2O3S
Molar mass	244.31 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(Nc1cc(ccc1)C(O)CNC)C
InChI InChI=1S/C10H16N2O3S/c1-11-7-10(13)8-4-3-5-9(6-8)12-16(2,14)15/h3-6,10-13H,7H2,1-2H3 Y Key:ZHOWHMXTJFZXRB-UHFFFAOYSA-N Y
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