Anhalidine

Anhalidine is a naturally occurring tetrahydroisoquinoline alkaloid found in Lophophora williamsii (peyote);^[1] it has also been detected in other cactii^[2] and several species of Acacia.^[3][4] It is part of a family of compounds that are structurally related to mescaline. Anhalidine has been found to act as a potent inverse agonist of the serotonin 5-HT₇ receptor.^[5]

Other namesN-Methylanhalamine; 8-Hydroxy-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; 8-Hydroxy-6,7-dimethoxy-2-methyl-THIQ

Drug classSerotonin 5-HT₇ receptor inverse agonist

ATC code

• None

CAS Number

• 2245-94-5 ^Y

Quick facts Clinical data, Other names ...

Anhalidine

Clinical data
Other names	N-Methylanhalamine; 8-Hydroxy-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; 8-Hydroxy-6,7-dimethoxy-2-methyl-THIQ
Drug class	Serotonin 5-HT7 receptor inverse agonist
ATC code	None
Identifiers
IUPAC name 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-8-ol
CAS Number	2245-94-5 Y
PubChem CID	2752318
ChemSpider	2033430
UNII	4E6N7C369C
CompTox Dashboard (EPA)	DTXSID60176992
Chemical and physical data
Formula	C12H17NO3
Molar mass	223.272 g·mol−1
3D model (JSmol)	Interactive image
SMILES OC1=C(C(OC)=CC2=C1CN(C)CC2)OC
InChI InChI=1S/C12H17NO3/c1-13-5-4-8-6-10(15-2)12(16-3)11(14)9(8)7-13/h6,14H,4-5,7H2,1-3H3 Key:DTXOXOHMRGAFDX-UHFFFAOYSA-N

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