Antazoline

Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.^[2] To treat allergic conjunctivitis, antazoline can be combined in a solution with tetryzoline.^[3] The drug is a Histamine H1 receptor antagonist:^[4] selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.

Trade namesVasocon-a

AHFS/Drugs.comMicromedex Detailed Consumer Information

Routes of
administrationTopical (nasal, eye drops)

ATC code

• R01AC04 (WHO) R06AX05 (WHO)

Quick facts Clinical data, Trade names ...

Antazoline

Clinical data
Trade names	Vasocon-a
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Topical (nasal, eye drops)
ATC code	R01AC04 (WHO) R06AX05 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) / Schedule 2[1]
Identifiers
IUPAC name N-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline
CAS Number	91-75-8
PubChem CID	2200
IUPHAR/BPS	7116
DrugBank	DB08799
ChemSpider	2115
UNII	DHA8014SS1
KEGG	D07458
ChEBI	CHEBI:84115
ChEMBL	ChEMBL1305
CompTox Dashboard (EPA)	DTXSID3022613
ECHA InfoCard	100.001.904
Chemical and physical data
Formula	C17H19N3
Molar mass	265.360 g·mol−1
3D model (JSmol)	Interactive image
SMILES N\1=C(\NCC/1)CN(c2ccccc2)Cc3ccccc3
InChI InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19) Key:REYFJDPCWQRWAA-UHFFFAOYSA-N

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