Arfendazam

Arfendazam (INN)^[1] is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.

ATC code

• none

CAS Number

• 37669-57-1 ^Y

PubChem CID

• 65803

ChemSpider

• 59219 ^Y

Quick facts Clinical data, ATC code ...

Arfendazam

Clinical data
ATC code	none
Identifiers
IUPAC name Ethyl 7-chloro-4-oxo-5-phenyl-2,3-dihydro-1,5-benzodiazepine-1-carboxylate
CAS Number	37669-57-1 Y
PubChem CID	65803
ChemSpider	59219 Y
UNII	P37G7BTX8V
ChEMBL	ChEMBL2104444 N
CompTox Dashboard (EPA)	DTXSID20191085
ECHA InfoCard	100.048.694
Chemical and physical data
Formula	C18H17ClN2O3
Molar mass	344.80 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClC1=CC2=C(C=C1)N(CCC(N2C3=CC=CC=C3)=O)C(OCC)=O
InChI InChI=1S/C18H17ClN2O3/c1-2-24-18(23)20-11-10-17(22)21(14-6-4-3-5-7-14)16-12-13(19)8-9-15(16)20/h3-9,12H,2,10-11H2,1H3 Y Key:NXJWVCHVPUCWJS-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABA_A receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses.^[2][3]

Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects.^[4]