B3GNT1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase is an enzyme that, in humans, is encoded by the B3GNT1 gene.[5][6]
| B4GAT1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | B4GAT1, B3GN-T1, B3GNT6, BETA3GNTI, MDDGA13, iGAT, iGNT, B3GNT1, beta-1,4-glucuronyltransferase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605517; MGI: 1919680; HomoloGene: 38239; GeneCards: B4GAT1; OMA:B4GAT1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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β-1,4-glucuronyltransferase
The B3GNT1 gene encodes a β-1,4-glucuronyltransferase, designated B4GAT1, that transfers glucuronic acid towards both α- and β-anomers of xylose.[7] B4GAT1 is the priming enzyme for LARGE, a dual-activity glycosyltransferase that is capable of extending products of B4GAT1. Thus, B4GAT1 is involved in the initiation of the LARGE-dependent repeating disaccharide that is necessary for extracellular matrix protein binding to O-mannosylated α-dystroglycan that is lacking in secondary dystroglycanopathies.
Misidentification
The B3GNT1 gene was first reported to encode a member of the beta-1,3-N-acetylglucosaminyltransferase family and thought to be responsible for the synthesis of poly-N-acetyllactosamine,[5] a determinant for the blood group i antigen. Thus, it was also known as iGNT.
