B4GALT5

Beta-1,4-galactosyltransferase 5 is an enzyme that in humans is encoded by the B4GALT5 gene.^[5][6][7]

AliasesB4GALT5, B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V, beta-1,4-galactosyltransferase 5

External IDsOMIM: 604016; MGI: 1927169; HomoloGene: 3507; GeneCards: B4GALT5; OMA:B4GALT5 - orthologs

Chr.Chromosome 20 (human)^[1]

End49,713,878 bp^[1]

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B4GALT5
Identifiers
Aliases	B4GALT5, B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V, beta-1,4-galactosyltransferase 5
External IDs	OMIM: 604016; MGI: 1927169; HomoloGene: 3507; GeneCards: B4GALT5; OMA:B4GALT5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 49,632,945 bp[1] End 49,713,878 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 167,140,364 bp[2] End 167,191,103 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium palpebral conjunctiva trachea trabecular bone pericardium mucosa of urinary bladder tibialis anterior muscle secondary oocyte pancreatic ductal cell olfactory zone of nasal mucosa Top expressed in gastrula yolk sac zygote decidua right kidney proximal tubule tail of embryo genital tubercle secondary oocyte spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity galactosyltransferase activity metal ion binding beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity N-acetyllactosamine synthase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity Cellular component integral component of membrane Golgi cisterna membrane Golgi membrane Golgi apparatus membrane Biological process protein glycosylation keratan sulfate biosynthetic process O-glycan processing carbohydrate metabolic process poly-N-acetyllactosamine biosynthetic process ganglioside biosynthetic process via lactosylceramide central nervous system neuron axonogenesis central nervous system myelination regulation of protein stability positive regulation of embryonic development neuron maturation lipid metabolism sphingolipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9334 56336 Ensembl ENSG00000158470 ENSMUSG00000017929 UniProt O43286 Q9JMK0 RefSeq (mRNA) NM_004776 NM_019835 RefSeq (protein) NP_004767 NP_062809 Location (UCSC) Chr 20: 49.63 – 49.71 Mb Chr 2: 167.14 – 167.19 Mb PubMed search [3] [4]
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This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2.^[7]