BACE1-AS
Non-coding RNA in the species Homo sapiens
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BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease.[2] BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.
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| Aliases | BACE1-AS, BACE1 antisense RNA, BACE1-AS1, FJ573250, NCRNA00177 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614263; GeneCards: BACE1-AS; OMA:BACE1-AS - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Knocking down BACE1-AS reduces amyloid production and plaque deposition.[3]