BAMBI
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
BMP and activin membrane-bound inhibitor homolog, also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[5][6]
AliasesBAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
External IDsOMIM: 604444; MGI: 1915260; HomoloGene: 8215; GeneCards: BAMBI; OMA:BAMBI - orthologs
Function
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family. The encoded protein is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta. Therefore, this has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[5]