BAMBI

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

BMP and activin membrane-bound inhibitor homolog, also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[5][6]

AliasesBAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
End28,682,932 bp[1]
Quick facts Identifiers, Aliases ...
BAMBI
Identifiers
AliasesBAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
External IDsOMIM: 604444; MGI: 1915260; HomoloGene: 8215; GeneCards: BAMBI; OMA:BAMBI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012342

NM_026505

RefSeq (protein)

NP_036474

NP_080781

Location (UCSC)Chr 10: 28.68 – 28.68 MbChr 18: 3.51 – 3.52 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family. The encoded protein is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta. Therefore, this has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[5]

References

Further reading

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