HLA-B associated transcript 3

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesBAG6, BAG-6, BAT3, D6S52E, G3, HLA-B associated transcript 3, BCL2 associated athanogene 6, BAG cochaperone 6

External IDsOMIM: 142590; MGI: 1919439; HomoloGene: 3409; GeneCards: BAG6; OMA:BAG6 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts BAG6, Available structures ...

BAG6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WX9, 4DWF, 4EEW, 4WWR, 4X86, 2N9P
Identifiers
Aliases	BAG6, BAG-6, BAT3, D6S52E, G3, HLA-B associated transcript 3, BCL2 associated athanogene 6, BAG cochaperone 6
External IDs	OMIM: 142590; MGI: 1919439; HomoloGene: 3409; GeneCards: BAG6; OMA:BAG6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,639,028 bp[1] End 31,652,705 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.59 cM Start 35,135,178 bp[2] End 35,147,322 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right lobe of thyroid gland right uterine tube apex of heart pituitary gland ganglionic eminence left lobe of thyroid gland anterior pituitary muscle of thigh Top expressed in seminiferous tubule spermatid spermatocyte neural layer of retina ventricular zone muscle of thigh superior frontal gyrus dentate gyrus of hippocampal formation granule cell yolk sac lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribosome binding misfolded protein binding Hsp70 protein binding polyubiquitin modification-dependent protein binding proteasome binding protein binding ubiquitin-specific protease binding ubiquitin protein ligase binding signaling receptor binding identical protein binding Cellular component cytoplasm cytosol membrane intracellular membrane-bounded organelle nucleoplasm BAT3 complex nucleus extracellular region extracellular exosome Biological process regulation of apoptotic process negative regulation of proteolysis intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator cell differentiation ubiquitin-dependent protein catabolic process kidney development embryo development lung development immune system process positive regulation of ERAD pathway protein stabilization negative regulation of apoptotic process internal peptidyl-lysine acetylation brain development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of cell population proliferation synaptonemal complex assembly spermatogenesis negative regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to cytosolic proteasome complex involved in ERAD pathway maintenance of unfolded protein involved in ERAD pathway tail-anchored membrane protein insertion into ER membrane ER-associated misfolded protein catabolic process immune response-activating cell surface receptor signaling pathway apoptotic process natural killer cell activation proteasomal protein catabolic process ubiquitin-dependent ERAD pathway endoplasmic reticulum stress-induced pre-emptive quality control transport chromatin organization proteasome-mediated ubiquitin-dependent protein catabolic process regulation of embryonic development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7917 224727 Ensembl ENSG00000204463 ENSG00000228760 ENSG00000234651 ENSG00000229524 ENSG00000096155 ENSG00000227761 ENSG00000233348 ENSMUSG00000024392 UniProt P46379 Q9Z1R2 RefSeq (mRNA) NM_001098534 NM_001199697 NM_001199698 NM_004639 NM_080702 NM_080703 NM_001252468 NM_001252469 NM_057171 RefSeq (protein) NP_001092004 NP_001186626 NP_001186627 NP_542433 NP_542434 NP_001239397 NP_001239398 NP_476512 NP_001359189 NP_001359190 NP_001359191 NP_001359194 NP_001359195 NP_001359196 NP_001359197 NP_001359198 NP_001359199 NP_001359200 NP_001359201 NP_001359202 NP_001359203 NP_001359204 NP_001359205 NP_001359206 NP_001359207 NP_001359208 NP_001359209 NP_001359210 NP_001359211 NP_001359212 NP_001359213 NP_001359214 NP_001359215 NP_001359216 NP_001359217 NP_001359218 NP_001359219 NP_001359220 NP_001391257 NP_001391258 NP_001391259 NP_001391260 NP_001391256 Location (UCSC) Chr 6: 31.64 – 31.65 Mb Chr 17: 35.14 – 35.15 Mb PubMed search [3] [4]
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A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There are three alternatively spliced transcript variants described for this gene.^[6]