BCAS3
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.[5][6] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[6]
Function
The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).[7] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.[8][better source needed] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.[8][better source needed]
