BCLAF1

Bcl-2-associated transcription factor 1 is a Bcl-2 family protein in humans that is encoded by the BCLAF1 gene.^[5][6][7]

AliasesBCLAF1, BTF, bK211L9.1, BCL2 associated transcription factor 1

External IDsOMIM: 612588; MGI: 1917580; HomoloGene: 8832; GeneCards: BCLAF1; OMA:BCLAF1 - orthologs

Chr.Chromosome 6 (human)^[1]

End136,289,851 bp^[1]

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BCLAF1
Identifiers
Aliases	BCLAF1, BTF, bK211L9.1, BCL2 associated transcription factor 1
External IDs	OMIM: 612588; MGI: 1917580; HomoloGene: 8832; GeneCards: BCLAF1; OMA:BCLAF1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.3 Start 136,256,627 bp[1] End 136,289,851 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A3 Start 20,312,469 bp[2] End 20,344,613 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibia embryo caput epididymis ventricular zone skin of thigh parietal pleura corpus epididymis epithelium of nasopharynx skin of hip Top expressed in genital tubercle tail of embryo ventricular zone abdominal wall pineal gland aortic valve Gonadal ridge Rostral migratory stream neural layer of retina maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding RNA binding Cellular component cytoplasm nuclear speck nucleus nucleoplasm Biological process positive regulation of apoptotic process regulation of DNA-templated transcription in response to stress negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of intrinsic apoptotic signaling pathway positive regulation of DNA-templated transcription, initiation positive regulation of response to DNA damage stimulus transcription, DNA-templated apoptotic process cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9774 72567 Ensembl ENSG00000029363 ENSMUSG00000037608 UniProt Q9NYF8 Q8K019 RefSeq (mRNA) NM_001077440 NM_001077441 NM_001301038 NM_014739 NM_001363659 NM_001025392 NM_001025393 NM_001025394 NM_153787 RefSeq (protein) NP_001070908 NP_001070909 NP_001287967 NP_055554 NP_001350588 NP_001020563 NP_001020564 NP_722482 Location (UCSC) Chr 6: 136.26 – 136.29 Mb Chr 10: 20.31 – 20.34 Mb PubMed search [3] [4]
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This gene encodes a transcriptional repressor that interacts with several members of the BCL-2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different protein isoforms have been found for this gene.^[7]