BD1008

BD1008 or N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor.^[1]

CAS Number

• 138356-08-8 ^Y

PubChem CID

• 126388

ChemSpider

• 112324

UNII

• JCY43QE7FQ

Quick facts Identifiers, CAS Number ...

BD1008

Identifiers
IUPAC name N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-1-pyrrolidineethanamine
CAS Number	138356-08-8 Y
PubChem CID	126388
ChemSpider	112324
UNII	JCY43QE7FQ
CompTox Dashboard (EPA)	DTXSID60160639
Chemical and physical data
Formula	C15H22Cl2N2
Molar mass	301.26 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(CCc1ccc(c(c1)Cl)Cl)CCN2CCCC2
InChI InChI=1S/C15H22Cl2N2/c1-18(10-11-19-7-2-3-8-19)9-6-13-4-5-14(16)15(17)12-13/h4-5,12H,2-3,6-11H2,1H3 Key:ASGIQUHBAVIOTI-UHFFFAOYSA-N

Close

Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1008 significantly attenuates the behavioral toxicity of cocaine, and may be potentially useful in the development of antidotes for the treatment of cocaine overdose.^[1][2][3][4]