BD1063

BD1063 or 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 9 ± 1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor.^[1]

CAS Number

• 150208-28-9

ChemSpider

• 499765

UNII

• 5X4CA32SG5

CompTox Dashboard (EPA)

• DTXSID70341674

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BD1063

Identifiers
IUPAC name 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine
CAS Number	150208-28-9
ChemSpider	499765
UNII	5X4CA32SG5
CompTox Dashboard (EPA)	DTXSID70341674
ECHA InfoCard	100.229.843
Chemical and physical data
Formula	C13H18Cl2N2
Molar mass	273.20 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CCN(CC1)CCc2ccc(c(c2)Cl)Cl
InChI InChI=1S/C13H18Cl2N2/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11/h2-3,10H,4-9H2,1H3 Key:SUIZRDJCBVPASY-UHFFFAOYSA-N

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Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine.^[1]

In other animal studies, BD1063 blocks the effects of MDMA,^[2] and reduces alcohol intake in rodent models of alcoholism.^[3]