Bone morphogenetic protein 10

Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.^[5][6]

AliasesBMP10, entrez:27302, bone morphogenetic protein 10

External IDsOMIM: 608748; MGI: 1338820; HomoloGene: 7644; GeneCards: BMP10; OMA:BMP10 - orthologs

Chr.Chromosome 2 (human)^[1]

End68,871,397 bp^[1]

Quick facts BMP10, Identifiers ...

BMP10
Identifiers
Aliases	BMP10, entrez:27302, bone morphogenetic protein 10
External IDs	OMIM: 608748; MGI: 1338820; HomoloGene: 7644; GeneCards: BMP10; OMA:BMP10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 68,860,909 bp[1] End 68,871,397 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 87,405,976 bp[2] End 87,414,659 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium right auricle of heart right lobe of liver tibialis anterior muscle mucosa of ileum left ventricle gastric mucosa placenta gastrocnemius muscle blood Top expressed in atrium atrioventricular valve primordial ventricle bulbus cordis myocardium of atrium endocardial cushion cardiac muscle tissue of atrium CA3 field perirhinal cortex ventricle of the heart More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity receptor serine/threonine kinase binding hormone activity telethonin binding protein binding transforming growth factor beta receptor binding growth factor activity Cellular component cytoplasm extracellular region cell surface Z discdkac extracellular space Biological process regulation of apoptotic process pathway-restricted SMAD protein phosphorylation regulation of MAPK cascade heart trabecula formation SMAD protein signal transduction negative regulation of cardiac muscle hypertrophy adult heart development positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of sarcomere organization positive regulation of cell proliferation involved in heart morphogenesis cardiac muscle cell proliferation positive regulation of cardiac muscle hypertrophy negative regulation of endothelial cell migration positive regulation of transcription, DNA-templated ventricular cardiac muscle tissue morphogenesis multicellular organism development development of the heart positive regulation of gene expression cell adhesion negative regulation of cell migration positive regulation of cardiac muscle cell proliferation positive regulation of cartilage development negative regulation of cell growth regulation of cardiac muscle hypertrophy in response to stress atrial cardiac muscle tissue morphogenesis regulation of cardiac muscle contraction sarcomere organization ventricular cardiac muscle cell development activin receptor signaling pathway BMP signaling pathway regulation of signaling receptor activity cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27302 12154 Ensembl ENSG00000163217 ENSMUSG00000030046 UniProt O95393 Q9R229 RefSeq (mRNA) NM_014482 NM_009756 RefSeq (protein) NP_055297 NP_033886 Location (UCSC) Chr 2: 68.86 – 68.87 Mb Chr 6: 87.41 – 87.41 Mb PubMed search [3] [4]
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BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.^[6] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.

BMP10 has also emerged as a novel atrial specific biomarker used in cardiovascular research, especially in the field of atrial fibrillation (AF). Latest research has revealed strong associations between plasma concentration of BMP10 and the risk for ischemic stroke in patients with atrial fibrillation as well as with the risk of AF recurrence after ablation for AF^[7][8].