BMS-F

BMS-F
Identifiers
	IUPAC name (S)-2-{[7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-indole-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester;
CAS Number	354569-07-6 ;
PubChem CID	10227614;
ChemSpider	8403104;
ChEMBL	ChEMBL311690;
Chemical and physical data
Formula	C27H33N3O5
Molar mass	479.577 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C2=C(N1CCN3CCOCC3)C(=CC=C2)OC)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)OC;
	InChI InChI=1S/C27H33N3O5/c1-19-24(26(31)28-22(27(32)34-3)18-20-8-5-4-6-9-20)21-10-7-11-23(33-2)25(21)30(19)13-12-29-14-16-35-17-15-29/h4-11,22H,12-18H2,1-3H3,(H,28,31)/t22-/m0/s1; Key:HQUJODHGYIPBGV-QFIPXVFZSA-N;

BMS-F is a chemical from the aminoalkylindole family invented by Bristol-Myers Squibb around 1999,^[1] that acts as a potent and selective agonist for the cannabinoid receptor CB₂, with a K_i of 8 nM at CB₂ and 500x selectivity over the related CB₁ receptor. It has antiinflammatory effects and inhibits release of TNF-α.^[2]^[3]

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Identifiers

IUPAC name (S)-2-{[7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-indole-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester
CAS Number	354569-07-6^Y
PubChem CID	10227614
ChemSpider	8403104
ChEMBL	ChEMBL311690
Chemical and physical data
Formula	C₂₇H₃₃N₃O₅
Molar mass	479.577 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=C(C2=C(N1CCN3CCOCC3)C(=CC=C2)OC)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)OC
InChI InChI=1S/C27H33N3O5/c1-19-24(26(31)28-22(27(32)34-3)18-20-8-5-4-6-9-20)21-10-7-11-23(33-2)25(21)30(19)13-12-29-14-16-35-17-15-29/h4-11,22H,12-18H2,1-3H3,(H,28,31)/t22-/m0/s1 Key:HQUJODHGYIPBGV-QFIPXVFZSA-N