BRD7

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesBRD7, BP75, CELTIX1, NAG4, bromodomain containing 7, SMARCI1
Quick facts Available structures, PDB ...
BRD7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRD7, BP75, CELTIX1, NAG4, bromodomain containing 7, SMARCI1
External IDsOMIM: 618489; MGI: 1349766; HomoloGene: 8085; GeneCards: BRD7; OMA:BRD7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001173984
NM_013263

NM_012047

RefSeq (protein)

NP_001167455
NP_037395

Location (UCSC)Chr 16: 50.31 – 50.37 MbChr 8: 88.33 – 88.36 Mb
PubMed search[3][4]
Wikidata
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Interactions

BRD7 has been shown to interact with IRF2[8] and HNRPUL1.[9]

Azoospermia

BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced.[10] Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.[10]

References

Further reading

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