BRD9

Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia

Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene. [5]

PDBOrtholog search: PDBe RCSB
AliasesBRD9, LAVS3040, PRO9856, bromodomain containing 9
Quick facts Available structures, PDB ...
BRD9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRD9, LAVS3040, PRO9856, bromodomain containing 9
External IDsOMIM: 618465; MGI: 2145317; HomoloGene: 82462; GeneCards: BRD9; OMA:BRD9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001009877
NM_023924
NM_001317951

NM_001024508
NM_001308041
NM_001378947
NM_001378948

RefSeq (protein)

NP_001019679
NP_001294970
NP_001365876
NP_001365877

Location (UCSC)Chr 5: 0.85 – 0.89 MbChr 13: 73.94 – 73.96 Mb
PubMed search[3][4]
Wikidata
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Structure and interaction

BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes.[6]

Role in cancer

The BRD9 gene is frequently present in variable copy number in lung cancer.[7]

Small molecule inhibition

Small molecules capable of binding to the bromodomain of BRD9 have been developed.[8][9][10]

See also

References

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