Interferon-induced transmembrane protein 5
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Interferon-induced transmembrane protein 5 is a gene that encodes a membrane protein thought to play a role in bone mineralization.
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| Aliases | IFITM5, interferon induced transmembrane protein 5, BRIL, DSPA1, Hrmp1, OI5, fragilis4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614757; MGI: 1934923; HomoloGene: 14210; GeneCards: IFITM5; OMA:IFITM5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Genomics
The gene is located on the short arm of the Crick strand of chromosome 11 (11p15.5). It is located with a cluster of interferon inducible genes but is itself not interferon inducible. The gene is 1,327 bases in length and encodes a protein of 132 amino acids with a predicted molecular weight of 14378 daltons. Expression in adults is bone specific and highest in osteoblasts. [citation needed]
The homolog in the mouse is located on chromosome 7. A homolog is also known to be present in lizards.[citation needed]
Evolution
The gene first appeared in bony fish and its bone specific expression appears to be limited to therian mammals.[citation needed]
Biochemistry
The protein has two transmembrane domains. It associates with FK506 binding protein 11.[5]
Clinical
Mutations in the gene are associated with osteogenesis imperfecta type 5.[6]