BZIP domain
Protein domain
From Wikipedia, the free encyclopedia
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.[1][2]
| bZIP transcription factor | |||||||
|---|---|---|---|---|---|---|---|
CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression. | |||||||
| Identifiers | |||||||
| Symbol | bZIP_1 | ||||||
| Pfam | PF00170 | ||||||
| InterPro | IPR011616 | ||||||
| PROSITE | PDOC00036 | ||||||
| SCOP2 | 1ysa / SCOPe / SUPFAM | ||||||
| CDD | cd14686 | ||||||
| Membranome | 235 | ||||||
| |||||||
bZIP transcription factors
bZIP transcription factors are found in all eukaryotes and form one of the largest families of dimerizing TFs.[3] An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants.[4] Interactions between bZIP transcription factors are numerous and complex [5][6][3] and play important roles in cancer development[7] in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues,[8] factors affecting reproductive functions,[9] and several other phenomena that affect human health.
bZIP domain containing proteins
- AP-1 fos/jun heterodimer that forms a transcription factor
- Jun-B transcription factor
- CREB cAMP response element transcription factor
- OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize (Zea mays) kernels
- NFE2L2 or Nrf2
- Bzip Maf transcription factors