Benzotript

Benzotript (INNTooltip International Nonproprietary Name), also known as N-(p-chlorobenzoyl)-L-tryptophan, is a muscle relaxant that inhibits gastric secretion and was never marketed.^[1][2] It is a tryptamine derivative and the N-(4-chlorobenzoyl) analogue of the amino acid tryptophan.^[1] Similarly to proglumide (N²-benzoyl-N,N-dipropyl-α-glutamine), the drug acts as a competitive and non-selective cholecystokinin receptor antagonist.^[2][3] Other more potent tryptophan derivatives have also been developed as cholecystokinin (CCK) antagonists.^[2]

Other namesBenzotrypt; CR-501; N-(p-Chlorobenzoyl)-L-tryptophan; N-(4-Chlorobenzoyl)-L-tryptophan; N-[(4-Chlorophenyl)carbonyl]tryptophan

CAS Number

• 39544-74-6

PubChem CID

• 2060890

ChemSpider

• 1553298

Quick facts Clinical data, Other names ...

Benzotript

Clinical data
Other names	Benzotrypt; CR-501; N-(p-Chlorobenzoyl)-L-tryptophan; N-(4-Chlorobenzoyl)-L-tryptophan; N-[(4-Chlorophenyl)carbonyl]tryptophan
Identifiers
IUPAC name (2S)-2-[(4-chlorobenzoyl)amino]-3-(1H-indol-3-yl)propanoic acid
CAS Number	39544-74-6
PubChem CID	2060890
ChemSpider	1553298
UNII	LS5O682BRO
ChEMBL	ChEMBL63544
CompTox Dashboard (EPA)	DTXSID501043305
ECHA InfoCard	100.049.528
Chemical and physical data
Formula	C18H15ClN2O3
Molar mass	342.78 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)C3=CC=C(C=C3)Cl
InChI InChI=1S/C18H15ClN2O3/c19-13-7-5-11(6-8-13)17(22)21-16(18(23)24)9-12-10-20-15-4-2-1-3-14(12)15/h1-8,10,16,20H,9H2,(H,21,22)(H,23,24)/t16-/m0/s1 Key:QJERBBQXOMUURJ-INIZCTEOSA-N

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