Bepridil

Calcium channel blocker medication From Wikipedia, the free encyclopedia

Bepridil (trade name Vascor) is an diamine calcium channel blocker once used to treat angina pectoris. It is no longer sold in the United States.

Trade namesVascor
AHFS/Drugs.comMonograph
MedlinePlusa699051
Routes of
administrationOral
Quick facts Clinical data, Trade names ...
Bepridil
Clinical data
Trade namesVascor
AHFS/Drugs.comMonograph
MedlinePlusa699051
Routes of
administration		Oral
ATC code
Pharmacokinetic data
BioavailabilityWell absorbed
Protein binding99%
MetabolismHepatic, CYP3A4-mediated
Elimination half-life42 hours
ExcretionRenal
Identifiers
  • N-benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H34N2O
Molar mass366.549 g·mol−1
3D model (JSmol)
  • O(CC(C)C)CC(N1CCCC1)CN(c2ccccc2)Cc3ccccc3
  • InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 checkY
  • Key:UIEATEWHFDRYRU-UHFFFAOYSA-N checkY
  (verify)
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It is nonselective.[1]

It has been discussed as a possible option in the treatment of atrial fibrillation.[2]

It has been implicated in causing ventricular arrhythmia (torsades de pointes).

Ebola research

In June 2015 a research paper [3] was published finding bepridil to result in a 100% survival rate for mice exposed to ebola during an experiment searching for potential pharmaceutical ebola treatments; indicating its potential use in future ebola research and therapy.[4]

SARS-CoV-2 research

A research paper [5] showed that Bepridil inhibited cytopathogenic effects induced by SARS-CoV-2 in Vero E6 cells and in A549 cells in an in vitro assay.

References

External links

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