IHCH-8134

IHCH-8134 is a serotonin 5-HT_2A receptor agonist of the oxazinopyridoindole family. It was derived by structural simplification of the serotonin 5-HT_2A receptor antagonist and atypical antipsychotic lumateperone. Another related compound is the pyridopyrroloquinoxaline IHCH-7079, which was found to be a non-hallucinogenic biased serotonin 5-HT_2A receptor agonist that was active in antidepressant assays but did not produce psychedelic-like responding in mice.^[1][2][3]

Drug classSerotonin 5-HT_2A receptor agonist

PubChem CID

• 172549469

FormulaC₂₃H₂₈N₂O₂

Molar mass364.489 g·mol⁻¹

Quick facts Clinical data, Drug class ...

IHCH-8134

Clinical data
Drug class	Serotonin 5-HT2A receptor agonist
Identifiers
IUPAC name (6bR,10aS)-8-(3-(2-methoxyphenyl)propyl)-1,2,6b,7,8,9,10,10a-octahydro-[1,4]oxazino[2,3,4-hi]pyrido[4,3-b]indole
PubChem CID	172549469
Chemical and physical data
Formula	C23H28N2O2
Molar mass	364.489 g·mol−1
3D model (JSmol)	Interactive image
SMILES [H][C@@]12[C@@](CCN(CCCC3=CC=CC=C3OC)C2)([H])N4CCOC5=C4C1=CC=C5
InChI InChI=1S/C23H28N2O2/c1-26-21-9-3-2-6-17(21)7-5-12-24-13-11-20-19(16-24)18-8-4-10-22-23(18)25(20)14-15-27-22/h2-4,6,8-10,19-20H,5,7,11-16H2,1H3/t19-,20-/m0/s1 Key:XIZOEKLHAJIDMD-PMACEKPBSA-N

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