GCFC2

GC-rich sequence DNA-binding factor is a protein that in humans is encoded by the GCFC2 gene.^[5][6][7][8]

AliasesGCFC2, C2orf3, DNABF, GCF, TCF9, GC-rich sequence DNA-binding factor 2

External IDsOMIM: 189901; MGI: 2141656; HomoloGene: 2411; GeneCards: GCFC2; OMA:GCFC2 - orthologs

Chr.Chromosome 2 (human)^[1]

End75,710,985 bp^[1]

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GCFC2
Identifiers
Aliases	GCFC2, C2orf3, DNABF, GCF, TCF9, GC-rich sequence DNA-binding factor 2
External IDs	OMIM: 189901; MGI: 2141656; HomoloGene: 2411; GeneCards: GCFC2; OMA:GCFC2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 75,652,000 bp[1] End 75,710,985 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 81,923,669 bp[2] End 81,959,915 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone gastrocnemius muscle right lobe of liver Achilles tendon muscle of thigh canal of the cervix right uterine tube body of pancreas gonad ectocervix Top expressed in hand superior cervical ganglion tail of embryo otolith organ utricle foot epiblast genital tubercle Rostral migratory stream ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding Cellular component nucleolus nucleus U2-type post-mRNA release spliceosomal complex nucleoplasm cytosol Biological process mRNA processing spliceosomal complex assembly negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6936 330361 Ensembl ENSG00000005436 ENSMUSG00000035125 UniProt P16383 Q8BKT3 RefSeq (mRNA) NM_001201334 NM_001201335 NM_003203 NM_177884 RefSeq (protein) NP_001188263 NP_001188264 NP_003194 NP_808552 Location (UCSC) Chr 2: 75.65 – 75.71 Mb Chr 6: 81.92 – 81.96 Mb PubMed search [3] [4]
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The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.^[8]