CADM3

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesCADM3, BIgR, IGSF4B, NECL1, Necl-1, TSLL1, synCAM3, cell adhesion molecule 3, CMT2FF

External IDsOMIM: 609743; MGI: 2137858; HomoloGene: 10919; GeneCards: CADM3; OMA:CADM3 - orthologs

Chr.Chromosome 1 (human)^[1]

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CADM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z9M
Identifiers
Aliases	CADM3, BIgR, IGSF4B, NECL1, Necl-1, TSLL1, synCAM3, cell adhesion molecule 3, CMT2FF
External IDs	OMIM: 609743; MGI: 2137858; HomoloGene: 10919; GeneCards: CADM3; OMA:CADM3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 159,171,609 bp[1] End 159,203,313 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 173,160,825 bp[2] End 173,195,261 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right frontal lobe tibial nerve anterior cingulate cortex nucleus accumbens Brodmann area 9 prefrontal cortex sural nerve amygdala Top expressed in cerebellar cortex neural layer of retina superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell piriform cortex lobe of cerebellum cerebellar vermis motor neuron sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding protein homodimerization activity cell adhesion molecule binding Cellular component integral component of membrane cell junction plasma membrane integral component of plasma membrane membrane cell-cell junction parallel fiber to Purkinje cell synapse integral component of presynaptic membrane Biological process protein localization heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell recognition adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57863 94332 Ensembl ENSG00000162706 ENSMUSG00000005338 UniProt Q8N126 Q99N28 RefSeq (mRNA) NM_021189 NM_001127173 NM_001346510 NM_053199 RefSeq (protein) NP_001120645 NP_001333439 NP_067012 NP_444429 Location (UCSC) Chr 1: 159.17 – 159.2 Mb Chr 1: 173.16 – 173.2 Mb PubMed search [3] [4]
Wikidata
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IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005).^[6]