CADPS

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesCADPS, CADPS1, CAPS, CAPS1, UNC-31, Ca2+ dependent secretion activator, calcium dependent secretion activator

External IDsOMIM: 604667; MGI: 1350922; HomoloGene: 2755; GeneCards: CADPS; OMA:CADPS - orthologs

Chr.Chromosome 3 (human)^[1]

Quick facts Available structures, PDB ...

CADPS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WI1
Identifiers
Aliases	CADPS, CADPS1, CAPS, CAPS1, UNC-31, Ca2+ dependent secretion activator, calcium dependent secretion activator
External IDs	OMIM: 604667; MGI: 1350922; HomoloGene: 2755; GeneCards: CADPS; OMA:CADPS - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.2 Start 62,398,346 bp[1] End 62,875,416 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A1 Start 12,372,563 bp[2] End 12,823,079 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons Brodmann area 46 prefrontal cortex Brodmann area 9 cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum right frontal lobe superior frontal gyrus postcentral gyrus Top expressed in pontine nuclei medial vestibular nucleus dorsal tegmental nucleus deep cerebellar nuclei mammillary body ventral tegmental area dorsomedial hypothalamic nucleus superior colliculus medial geniculate nucleus lateral geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein kinase binding metal ion binding lipid binding Cellular component membrane cytoplasmic vesicle cytosol cell junction synapse cytoplasmic vesicle membrane presynapse glutamatergic synapse Biological process protein transport synaptic vesicle priming catecholamine secretion vesicle organization exocytosis synaptic vesicle exocytosis dense core granule exocytosis presynaptic dense core vesicle exocytosis positive regulation of exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8618 27062 Ensembl ENSG00000163618 ENSMUSG00000054423 UniProt Q9ULU8 Q80TJ1 RefSeq (mRNA) NM_003716 NM_183393 NM_183394 NM_001042617 NM_012061 NM_001359919 NM_001359920 NM_001359921 RefSeq (protein) NP_003707 NP_899630 NP_899631 NP_001036082 NP_036191 NP_001346848 NP_001346849 NP_001346850 Location (UCSC) Chr 3: 62.4 – 62.88 Mb Chr 14: 12.37 – 12.82 Mb PubMed search [3] [4]
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CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.^[6]