CALML5

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesCALML5, CLSP, calmodulin like 5

External IDsOMIM: 605183; MGI: 1931464; HomoloGene: 49485; GeneCards: CALML5; OMA:CALML5 - orthologs

Chr.Chromosome 10 (human)^[1]

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CALML5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B1U
Identifiers
Aliases	CALML5, CLSP, calmodulin like 5
External IDs	OMIM: 605183; MGI: 1931464; HomoloGene: 49485; GeneCards: CALML5; OMA:CALML5 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 5,498,697 bp[1] End 5,499,570 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 3,887,757 bp[2] End 3,888,673 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen vulva skin of leg human penis skin of thigh skin of hip skin of arm nipple minor salivary glands parotid gland Top expressed in lip skin of external ear esophagus umbilical cord skin of abdomen superior surface of tongue skin of back condyle fossa molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding enzyme regulator activity Cellular component extracellular region ficolin-1-rich granule lumen nucleus Biological process signal transduction epidermis development neutrophil degranulation calcium-mediated signaling regulation of catalytic activity spindle pole body organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51806 80796 Ensembl ENSG00000178372 ENSMUSG00000033765 UniProt Q9NZT1 Q9JM83 RefSeq (mRNA) NM_017422 NM_020036 RefSeq (protein) NP_059118 NP_064420 Location (UCSC) Chr 10: 5.5 – 5.5 Mb Chr 13: 3.89 – 3.89 Mb PubMed search [3] [4]
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This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.^[6]