Calmodulin-regulated spectrin-associated protein 3
Microtubule minus-end binding human protein
From Wikipedia, the free encyclopedia
Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha.
AliasesCAMSAP3, KIAA1543, NEZHA, PPP1R80, calmodulin regulated spectrin associated protein family member 3
External IDsOMIM: 612685; MGI: 1916947; HomoloGene: 18966; GeneCards: CAMSAP3; OMA:CAMSAP3 - orthologs
Function
CAMSAP3 acts as a minus-end anchor of microtubules, and binds to them through its CKK domain.[5]
In epithelial cells, it anchors microtubules to the apical cortex, causing them to grow in an apical-to-basal direction.[6] This gives the epithelial cells their rectangular shape.
In other species
In early mouse embryogenesis, the interphase bridge linking sister cells is enriched with CAMSAP3.[7]