Calpain-1 catalytic subunit

Protein found in humans From Wikipedia, the free encyclopedia

Calpain-1 catalytic subunit (CANP 1) is a protein that in humans is encoded by the CAPN1 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesCAPN1, CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1
Quick facts CAPN1, Available structures ...
CAPN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAPN1, CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1
External IDsOMIM: 114220; MGI: 88263; HomoloGene: 3800; GeneCards: CAPN1; OMA:CAPN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001198868
NM_001198869
NM_005186

NM_001110504
NM_007600

RefSeq (protein)

NP_001185797
NP_001185798
NP_005177

NP_001103974
NP_031626

Location (UCSC)Chr 11: 65.18 – 65.21 MbChr 19: 6.04 – 6.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.[7]

Interactions

CAPN1 has been shown to interact with PSEN2.[8]

References

Further reading

Related Articles

Wikiwand AI