CAPN5

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.^[5][6][7]

AliasesCAPN5, ADNIV, HTRA3, VRNI, nCL-3, calpain 5

External IDsOMIM: 602537; MGI: 1100859; HomoloGene: 31212; GeneCards: CAPN5; OMA:CAPN5 - orthologs

Chr.Chromosome 11 (human)^[1]

End77,126,155 bp^[1]

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CAPN5
Identifiers
Aliases	CAPN5, ADNIV, HTRA3, VRNI, nCL-3, calpain 5
External IDs	OMIM: 602537; MGI: 1100859; HomoloGene: 31212; GeneCards: CAPN5; OMA:CAPN5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.5 Start 77,066,961 bp[1] End 77,126,155 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 98,121,559 bp[2] End 98,178,274 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum gallbladder right lobe of liver stromal cell of endometrium mucosa of esophagus duodenum body of stomach mucosa of ileum palpebral conjunctiva Top expressed in transitional epithelium of urinary bladder lumbar spinal ganglion pyloric antrum epithelium of stomach conjunctival fornix mucous cell of stomach perirhinal cortex fetal liver hematopoietic progenitor cell corneal stroma entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity hydrolase activity calcium-dependent cysteine-type endopeptidase activity Cellular component cell surface extracellular exosome intracellular anatomical structure focal adhesion cytoplasm Biological process signal transduction proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 726 12337 Ensembl ENSG00000149260 ENSMUSG00000035547 UniProt O15484 O08688 RefSeq (mRNA) NM_004055 NM_001301250 NM_007602 RefSeq (protein) NP_004046 NP_001288179 NP_031628 Location (UCSC) Chr 11: 77.07 – 77.13 Mb Chr 7: 98.12 – 98.18 Mb PubMed search [3] [4]
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Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.^[7]