CBLL1
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
The E3 ubiquitin-protein ligase Hakai (HAKAI) also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1 (CBLL1) is an enzyme that in humans is encoded by the CBLL1 gene.[5] This gene encodes an E3 ubiquitin ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation.
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| Aliases | CBLL1, HAKAI, RNF188, Cbl proto-oncogene like 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606872; MGI: 2144842; HomoloGene: 11734; GeneCards: CBLL1; OMA:CBLL1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Hakai functions as a RING finger domain-containing E3 ubiquitin ligase for E-cadherin. Hakai mediates E-cadherin ubiquitination and its degradation by proteasomes. "Hakai" means "destruction" in Japanese. Proteosomal degradation of E-cadherin can be regulated by phosphorylation. The Hakai binding site is a part of the E-cadherin cytoplasmic domain that contains several tyrosines.[6] Tyrosine kinases such as Src and Met can phosphorylate E-cadherin and enhance Hakai binding to E-cadherin.[7] Two lysines of the E-cadherin cytoplasmic domain have been shown to be sites for ubiquitination.[8] Hakai also interacts with polypyrimidine tract-binding protein-associated splicing factor.[9]
See also
- CBL (gene); the gene name "CBLL1" comes from "Cbl-like protein 1"
