Protein chibby homolog 1

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesCBY1, C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1, chibby homolog 1 (Drosophila), chibby family member 1, beta catenin antagonist, Chibby1
Quick facts CBY1, Available structures ...
CBY1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBY1, C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1, chibby homolog 1 (Drosophila), chibby family member 1, beta catenin antagonist, Chibby1
External IDsOMIM: 607757; MGI: 1920989; HomoloGene: 12514; GeneCards: CBY1; OMA:CBY1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015373
NM_001002880

NM_028634

RefSeq (protein)

NP_001002880
NP_056188

NP_082910

Location (UCSC)Chr 22: 38.66 – 38.67 MbChr 15: 79.54 – 79.55 Mb
PubMed search[3][4]
Wikidata
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Function

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

CBY1 has been shown to interact with Beta-catenin.[8] CBY1 has also been shown to interact with CEP164, CIBAR1 (FAM92A1), and RAB8A.[9]

References

Further reading

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