CCDC90B
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene. It is a mitochondrial calcium uniporter binding protein.[5]
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| Aliases | CCDC90B, MDS011, MDS025, coiled-coil domain containing 90B | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1913615; HomoloGene: 23328; GeneCards: CCDC90B; OMA:CCDC90B - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene
CCDC90B is located on chromosome 11 in humans. It is neighbored by:[6]
- PCF11, a mammalian pre-mRNA cleavage complex 2 protein
- ANKRD42, ankyrin repeat protein involved with calcium ion bonding
- BC070093
- DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family
Structure
This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.
The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.
Properties
- Molecular Weight: 26.72 kDa
- Isoelectric point: 7.5
- Transmembrane Helices: None
Post-translation modifications:[7]
- Chloroplast transit peptides: None
- Signal pepties: None
- C-mannosylation sites: None
- N-glycosylation sites: None
- Mitochondrial targeting: Yes
- Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP
It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.