C-C motif chemokine ligand 27
Mammalian protein found in humans
From Wikipedia, the free encyclopedia
C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. [5]
Function
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.[6][7] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.[8] The gene for CCL27 is located on human chromosome 9.[9] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].
